Pharmacother. 2023 Jan 16;28(2):906. doi: 10.3390/molecules28020906. In addition, (Bai et al., 2013) reported that nanoparticle-mediated drug delivery to the tumor neovasculature was able to overcome P-gp-expressing multidrug resistant cancer by targeting KDR receptors, which are highly expressed in the tumor vasculature. doi: 10.1016/j.jare.2019.02.036, Legge, C. J., Colley, H. E., Lawson, M. A., and Rawlings, A. E. (2019). doi: 10.2174/1389450117666160602202339. Control Release 245, 4151. Pharm. Wiley Interdiscip. The organic NPs contain liposome-based NPs, polymer-based NPs and dendrimers. Res. Progress and perspective of inorganic nanoparticle-based siRNA delivery systems. Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy. Nanotechnology has the potential to increase the selectivity and potency of chemical, physical, and biological approaches for eliciting cancer cell death while minimizing collateral toxicity to. BMC Cancer 9:399. doi: 10.1186/1471-2407-9-399, Sykes, E. A., Chen, J., Zheng, G., and Chan, W. C. (2014). 63, 170183. Sci. Adv. The nanoparticle-based drug delivery system can modify the control of drug release. 25, 606635. (2019). Eur. Liposomal doxorubicin has been proven to reduce cardiotoxicity and has comparable efficacy in breast cancer (OBrien et al., 2004; Geisberg and Sawyer, 2010). 10. Compared to conventional drugs, nanoparticle-based drug delivery has specific advantages, such as improved stability and biocompatibility, enhanced permeability and retention effect, and precise targeting. doi: 10.1038/nrc724, Saad, M., Garbuzenko, O. doi: 10.1002/cmdc.200800122, Alimoradi, H., Greish, K., Barzegar-Fallah, A., Alshaibani, L., and Pittal, V. (2018). (2017). Ther. Epub 2019 Nov 9. Overcoming STC2 mediated drug resistance through drug and gene co-delivery by PHB-PDMAEMA cationic polyester in liver cancer cells. Pharm. However, it does have some drawbacks, for example, toxicity, environmental harm and organ damage caused by nanoparticles. Brocato, T.A. Nanotechnology applied to cancer therapy has led to a new era of cancer treatment. Targeting the immunosuppressive TME is mainly achieved by targeting tumor-associated macrophages (TAMs), myeloid derived suppressor cells (MDSCs), and regulatory T cells (Tregs), all of which are important cell types in the TME (Shao et al., 2015). New insights into designing hybrid nanoparticles for lung cancer: diagnosis and treatment. doi: 10.1039/c4nr02187h, Amreddy, N., Babu, A., Muralidharan, R., Panneerselvam, J., Srivastava, A., Ahmed, R., et al. 27, 255264. Cancer Lett. Due to better pharmacokinetics and treatment efficacy, as well as high stability, SNPs are considered one of the best vehicles for drug delivery (Zhang F. et al., 2017; Xu et al., 2019). the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Top. The gold core is inert and non-toxic, and surface-functionalized AuNPs have been proven to enhance drug accumulation in tumors as well as to overcome the drug resistance (Cheng et al., 2013). These ligands specifically bind to receptors on targeted cells, and the widely investigated receptors include transferrin receptor, folate receptor, glycoproteins, and the epidermal growth factor receptor (EGFR). This type of tumor has special characteristics that allow the improvement of diagnostic and treatment techniques used in clinical practice, by combining nanotechnology . | Epub 2015 Mar 23. Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity. Overcoming Ovarian Cancer Drug Resistance with a Cold Responsive Nanomaterial. To some extends, several types of cancers are avoidable by modifying unhealthy lifestyle habits. Moreover, half-shells of metal multilayers (such as manganese and gold) and PLGA hybrid NPs have the potential of combining targeted drug delivery and hyperthermia, which can enhance the destruction of tumor cells (Park et al., 2009). J. Pharm. Nanoparticle-mediated wild-type p53 gene delivery results in sustained antiproliferative activity in breast cancer cells. For example, one study showed that co-loading of the chemotherapeutic agent Nutlin-3a and the cytokine GM-CSF in spermine-modified AcDEX NPs led to improved proliferation of cytotoxic CD8(+) T cells and stimulated immune response, leading to tumor cell death while avoiding toxicity in immune cells (Bauleth-Ramos et al., 2017). Lipid-polymer hybrid NPs, which consist of an inner polymeric core and a lipid shell, have been demonstrated to be a promising drug delivery platform in the treatment of pancreatic cancer (Hu et al., 2010; Zhao et al., 2015), breast cancer (Gao et al., 2017; Li et al., 2019), and metastatic prostate cancer (Wang Q. et al., 2017). Current methods used for chemotherapy have various limitations, such as cytotoxicity, multi-drug resistance, stem-like cells growth, and lack of specificity. Liposome, the first nano-scale drug approved for clinical application (Zylberberg and Matosevic, 2016), consists of an outer lipid layer and a core entrapping either hydrophobic or hydrophilic drug. doi: 10.1002/jbm.a.36515, Zang, X., Zhao, X., Hu, H., Qiao, M., Deng, Y., and Chen, D. (2017). J. Nanomed. (2019). Co-delivery of PDTC and doxorubicin by multifunctional micellar nanoparticles to achieve active targeted drug delivery and overcome multidrug resistance. Nanotechnology presents numerous potential benefits to cancer treatment, identification, and diagnosis. J. Breast cancer is associated with high morbidity and mortality and is the second leading cause of death in Western countries. 24 April 2020. Some NPs do not directly target cancer cells but instead have an effect on angiogenesis, which is another method of cancer treatment. Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. doi: 10.1096/fj.12-218081, Park, H., Yang, J., Lee, J., Haam, S., Choi, I. H., and Yoo, K. H. (2009). Cancer 10, 922. In addition to directly inhibiting the function of HIF-1, indirect inhibition of HIF-1 signaling has also been previously considered. (2010). Oncogene 25, 46334646. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth. The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter. The https:// ensures that you are connecting to the 4:143. doi: 10.3389/fphar.2013.00143, Iwase, Y., and Maitani, Y. doi: 10.1016/j.biomaterials.2018.10.019, Lia, N. G., Shib, Z. H., Tang, Y. P., and Duan, J. Biomaterials 178, 597607. J. Nanomed. These results show the effective induction of apoptosis and inhibition of tumor growth. HHS Vulnerability Disclosure, Help Nanomaterials used in cancer therapy can be classified into several main . (2014). doi: 10.1016/j.ijpharm.2004.07.019, Kong, F., Zhang, X., Zhang, H. B., Qu, X. M., Chen, D., Servos, M., et al. In passive targeting, the drugs are successfully delivered to the target site in order to play a therapeutic role. An official website of the United States government. The LSH nanoparticle has also been reported to offer a platform for the synergistic delivery of gemcitabine and paclitaxel to pancreatic cancer in a mouse model of the disease (Meng et al., 2015). Mater. doi: 10.1016/j.biomaterials.2010.03.066, Fang, R. H., Kroll, A. V., Gao, W., and Zhang, L. (2018). 2023 Jan 20;14(2):58. doi: 10.3390/jfb14020058. ACS Nano 2, 16961702. Targeted magnetic nanoparticle hyperthermia for the treatment of oral cancer. An official website of the United States government. C Mater. 8600 Rockville Pike | Drug targeting to the colon with lectins and neoglycoconjugates. Silencing the HIF-1 gene is one of the ways to inhibit hypoxic environment. Nanotechnology based imaging contrast agents being developed and translated today, offer the ability to specifically target and greatly enhance detection of tumor in vivo by way of conventional scanning devices, such as magnetic resonance imaging (MRI), (PET), and computed tomography (CT). They have been shown to demonstrate high efficacy in chemotherapy and gene therapy for cancer treatment (Basoglu et al., 2018; Mandriota et al., 2019). Nanoparticles are classified into several main categories. Would you like email updates of new search results? (1992). official website and that any information you provide is encrypted doi: 10.1016/j.ijpharm.2017.06.071, Chen, Y., Gao, D. Y., and Huang, L. (2015). doi: 10.1016/j.drudis.2010.08.006, Misra, R., and Sahoo, S. K. (2011). Rhoda K, Choonara YE, Kumar P, Bijukumar D, du Toit LC, Pillay V. Expert Opin Drug Deliv. Erythrocyte-Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal/Chemotherapy of Melanoma. Curr. Mechanically, nano-carriers in cancer therapy target to tumor cells through the carrier effect of NPs and the positioning effect of the targeting substance after being absorbed. Med. Nat. (2019). Their multiple functional groups on the surface enhance the capability of loading and delivering therapeutic agents. Several studies have reported the effectiveness of nanosystems containing HIF-1 siRNA to overcome drug resistance in cancer (Zhao et al., 2015; Luan et al., 2018; Hajizadeh et al., 2020). Compared to traditional drugs, NP-based drug delivery systems are associated with improved pharmacokinetics, biocompatibility, tumor targeting, and stability, while simultaneously playing a significant role in reducing systemic toxicity and overcoming drug resistance. Epub 2020 Jan 21. Parodi et al. Furthermore, in order to minimize interactions with the reticuloendothelial system, NPs are usually modified with PEG (Zang et al., 2017). (2008). Several applications of ozonation were examined in this study for: i. the treatment of stabilized high strength municipal landfill leachates, ii. Programmable nanoparticle functionalization for in vivo targeting. Mater. In addition, high expression of P-gp has been associated with poor treatment-response in many tumors, such as breast (Chintamani et al., 2005) and ovarian cancer (Agarwal and Kaye, 2003). Mol. Advantages and Limitations of Nanotechnology in Cancer Treatment As with any new technology, there are both advantages and limitations to the use of nanotechnology in cancer treatment. A drug-delivering-drug strategy for combined treatment of metastatic breast cancer. The advantage of nanosized carriers is that they can increase the delivered drug's overall therapeutic index through nanoformulations in with chemotherapeutics are either encapsulated or conjugated to the surfaces of nanoparticles. J. Biomed. (2019). Evaluation of HIF-1 inhibitors as anticancer agents. J. 284, 109122. Multifunctional micelle delivery system for overcoming multidrug resistance of doxorubicin. doi: 10.1021/nn900215k, Parodi, A., Quattrocchi, N., van de Ven, A. L., Chiappini, C., Evangelopoulos, M., Martinez, J. O., et al. Cell 176, 12481264. Control Release 148, 135146. (2013). Given its better biocompatibility and biodegradation, as well as the EPR effect, PLGA is widely used as a carrier for drug delivery (Acharya and Sahoo, 2011; Saneja et al., 2019). Findings from the study showed that this NP complex impaired P-gp-induced drug efflux and the activation of apoptosis. Different types of nanoparticles (NPs) for cancer therapy. Biopharm. Before Mol. Chem. have reported the favorable treatment efficacy of cationic NPs coupled with an v3 integrin-targeting ligand for gene delivery into tumor-bearing mice (Hood et al., 2002). The clinical translation of organic nanomaterials for cancer therapy: a focus on polymeric nanoparticles, micelles, liposomes and exosomes. About 30% of cancer associated death are related to smoking, additional lifestyle factors , or dietetic practices. doi: 10.1002/hep.29681, Zhang, L., Chan, J. M., Gu, F. X., Rhee, J. W., Wang, A. Adv Drug Deliv Rev. Med. A., Unger, C., et al. Med. Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. Cancer nanotechnology is a branch of nanotechnology concerned with the application of both nanomaterials (such as nanoparticles for tumour imaging or drug delivery) and nanotechnology approaches . Recent advances with liposomes as pharmaceutical carriers. Therefore, NPs are generally modified to become hydrophilic, which increases the time period of drugs in circulation and enhances their penetration and accumulation in tumors (Perrault et al., 2009; Wong et al., 2011; Yang et al., 2014). Folate-targeted therapeutic and imaging agents for cancer. All authors approved the final version of the manuscript. FASEB J. Compared to unmodified NPs, transferrin-modified NPs have been shown to exhibit higher cellular uptake efficiency and enhanced intracellular delivery of drugs (Cui et al., 2017). The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. The experiment was successful and drastically shrunk the tumor, leaving the healthy cells unaffected. doi: 10.1007/s00432-016-2179-3, Saneja, A., Kumar, R., Mintoo, M. J., Dubey, R. D., Sangwan, P. L., Mondhe, D. M., et al. Immunotherapy of malignant tumor is a verified and crucial anti-tumor strategy to help patients with cancer for prolonging prognostic survival. The advent of nanotechnology has revolutionized . 02 March 2023, Research 2023 Feb 3;28(3):1506. doi: 10.3390/molecules28031506. This site needs JavaScript to work properly. J. Nanomed. Accessibility A single dose of carbon nanotubes enhances breast cancer metastasis in mouse models. On polymeric nanoparticles, micelles, liposomes and exosomes study for: the. 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